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Machu Picchu, Peru

Machu Picchu, Peru

Iguaçu National Park,Brazil

Iguaçu National Park,Brazil

Los Glaciares National Park, Argentina

Los Glaciares National Park, Argentina

Cordillera Paine, Chile

Cordillera Paine, Chile

Easter Island

Easter Island

Amazon River

Amazon River

Easter Island, Mysterious Moai

Easter Island, Mysterious Moai

Valparaiso, Chile

Valparaiso, Chile

La Serena, Chile (Punta Churos)

La Serena, Chile (Punta Churos)

Catedral de San Marcos, Arica

Catedral de San Marcos, Arica

Machu Picchu, Peru

Machu Picchu, Peru

El Faro Lighthouse, Mazatlan

El Faro Lighthouse, Mazatlan

South America Cruises Await You!

South America cruises offer unbelievable experiences that you'll never forget. On one of our cruises to South America from Florida, Los Angeles, or any of the other available ports, you'll learn about things like the native Amazonians and Peru's Nazca Lines, all while exploring breathtaking natural vistas and sampling exquisite South American cuisine. And when you book your cruise to South America with CruiseDirect, you'll do it all at the lowest possible price, thanks to our best price guarantee.

Book an Immersive South American Cruise Experience

While many cruises in South America are part of global itineraries, dedicated South America cruises with a focus on the Amazon and other key South American destinations provide an opportunity to immerse yourself in all of the experiences offered by this diverse continent. Whether you seek an extended trip or a shorter voyage, South American cruises from Florida and other ports provide an incredible variety of sights and activities. Witness Magellanic penguins nesting near Punta Arenas, soak up the sun in Rio de Janeiro, dance through the streets of Argentina, or enjoy a leisurely visit to Uruguay's largest winery. It's all at your fingertips with CruiseDirect!

Sail Aboard Top Cruise Lines Traveling Throughout South America

South America's landscapes are as varied as its cultures, ranging from the lush depths of the Amazon rainforest to the arid Atacama Desert and the breathtaking Chilean fjords, where towering glaciers dominate the scenery. Leading cruise lines such as OceaniaHolland AmericaPrincess, and Norwegian offer diverse itineraries, ensuring that there is a perfect cruise to South America from Florida for every traveler.

  • Destination Port 1 Departure Port
  • Destination port 2 Port of Call
Exclusive "End of the World" Drive
Exclusive "End of the World" Drive
$120

Experience rugged peaks, pristine lakes, ancient forests of the Andes, and the glacier-draped shores of the famed Beagle Channel.

Exclusive Punta Tombo Penguins
Exclusive Punta Tombo Penguins
$179

Visit the largest Magellan penguin colony in South America where you may walk among more than 500,000 penguins along a two-mile path.

Cartagena City Tour
Cartagena City Tour
$79

This fun adventure takes you around Cartagena for a close look at top attractions like Las Bovedas and Cartagena Bay. Entrance fees included.

Valparaiso and Vina Del Mar (Pre Cruise)
Valparaiso and Vina Del Mar (Pre Cruise)
$185

Enjoy a visit to a winery as well as the highlights of two beautiful coastal cities on this pre-cruise tour from Santiago to Valparaiso.

Best of Buenos Aires Bike Tour
Best of Buenos Aires Bike Tour
$100

On this bike tour of Buenos Aires's most fascinating places, you will experience the culture and history this city has to offer.

Half Day Los Andes to Valle Nevado and Farellones
Half Day Los Andes to Valle Nevado and Farellones
$124

Get ready for spectacular views of the Andes on this Chile tour that takes you to two of the mountain range's most popular ski resorts.

View All Excursions
Cruise Lines Apr 25 May 25 Jun 25 Jul 25 Aug 25 Sep 25 Oct 25 Nov 25 Dec 25 Jan 26 Feb 26 Mar 26
AmaWaterways   $3,839       $3,339 $3,339 $3,339 $3,539 $4,049 $4,049 $3,549
Atlas Ocean Voyages             $6,879          
Celebrity Cruises                 $1,986 $2,748 $1,961 $859
Costa $1,668             $533 $449 $1,025 $1,045 $571
Holland America Line               $1,799 $1,849 $3,914 $2,139 $2,139
Hurtigruten Expeditions                       $7,135
MSC Cruises $1,639           $372 $421 $349 $554 $452 $496
Oceania Cruises               $5,599 $5,799 $3,499 $4,099 $2,999
Princess Cruises               $2,098 $2,108 $3,198    
Regent Seven Seas                 $5,320 $14,799 $12,799  
Seabourn Cruise Line             $6,749 $14,598 $14,998 $16,598 $14,498 $11,198
Silversea Cruises             $12,800   $9,500 $11,600 $9,600 $15,500
Uniworld Boutique Cruises       $14,399 $14,399 $14,399 $14,399     $11,699 $11,699 $12,149
Viking Expeditions Cruises             $7,995         $8,995
Viking Ocean Cruises               $8,499 $7,999 $8,599 $8,999  
Windstar                 $7,757     $5,884

Monthly Weather Averages

The graph that represents the temperature in fahrenheit
month graph
The graph that represents the precipitation rate forecast in inches
  • Temperature in Fahrenheit
  • Rain in Inches

Current Weather

Buenos Aires
61°F
Rain
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Thursday

65° 60°

Friday

70° 60°

Saturday

63° 53°

Sunday

61° 57°

Fall in Love With Lively South America!

What Are the Best South America Cruises?

The best South America cruises have varied itineraries, including stops in Brazil, Argentina, Chile, and Peru. Look for cruises that provide unique experiences like visiting the Amazon River or exploring the Patagonian fjords. Voyages that allow travelers to immerse themselves in the natural wonders of the continent are some of the best South American cruises.

Which Cruise Lines Offer South American Cruises?

Major cruise lines offering South American cruises include:

When Is the Best Time to Take a Cruise to South America?

The best time for South American cruises is from December to March when the weather is warmest. In addition to offering the best cruises to South America, this period is also the peak season for Antarctic cruises.

Are There South American River Cruises Available?

Yes, South American river cruises are available. Popular South American river cruises include planned trips on the Amazon River and the Rio de la Plata.

Where Do South America Cruises Depart From?

You can find numerous South American cruises from Miami, Fort Lauderdale, Los Angeles, and numerous other departure ports, including: